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Applications

Research Area
Sample(Cell/DNA) Applications
Mammalian Pre-implantation genetic screening
Pre-implantation genetic diagnosis
Genotyping of transgenic animals
Phasing of individual human genomes
Genotyping of sperm cell
Embryo and stem cell
Forensic specimens analysis
Typing of transgenic animals
Cancer Somatic genetic variation analysis
Tumor evolution and development
Tumor stem cell
Circulating tumor cells
Bacteria Genotyping of microorganism
Metagenomics study
Pathogen analysis
MALBAC Major Citations

Cancer Biol Med. 2015 Sep;12(3):184-92. doi: 10.7497/j.issn.2095-3941.2015.0056.
Single-cell analyses of circulating tumor cells.
Chen XX1Bai F1.

Genetics. 2015 Sep;201(1):31-8. doi: 10.1534/genetics.115.179028. Epub 2015 Jun 26.
A Male-Specific Genetic Map of the Microcrustacean Daphnia pulex Based on Single-Sperm Whole-Genome Sequencing.
Xu S1Ackerman MS2Long H2Bright L2Spitze K2Ramsdell JS3Thomas WK3Lynch M2.

Annu Rev Genomics Hum Genet. 2015;16:79-102. doi: 10.1146/annurev-genom-090413-025352. Epub 2015 Jun 11.
Single-Cell Whole-Genome Amplification and Sequencing: Methodology and Applications.
Huang L1Ma FChapman ALu SXie XS.

Fertil Steril. 2014 Dec;102(6):1685-91. doi: 10.1016/j.fertnstert.2014.08.015. Epub 2014 Sep 17.
Validation of multiple annealing and looping-based amplification cycle sequencing for 24-chromosome aneuploidy screening of cleavage-stage
embryos.
Huang J1Yan L1Fan W2Zhao N3Zhang Y1Tang F2Xie XS4Qiao J5.

Anal Chem. 2014 Oct 7;86(19):9386-90. doi: 10.1021/ac5032176. Epub 2014 Sep 22.
Microfluidic whole genome amplification device for single cell sequencing.
Yu Z1Lu SHuang Y.

Cell. 2014 Jul 17;158(2):250-62. doi: 10.1016/j.cell.2014.06.037.
Conducting a microbiome study.
Goodrich JK1Di Rienzi SC1Poole AC1Koren O1Walters WA2Caporaso JG3Knight R4Ley RE5.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21083-8. doi: 10.1073/pnas.1320659110. Epub 2013 Dec 9.
Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients.
Ni X1Zhuo MSu ZDuan JGao YWang ZZong CBai HChapman ARZhao JXu LAn TMa QWang YWu MSun YWang SLi ZYang XYong JSu XDLu YBai FXie XSWang J.

Cell. 2013 Dec 19;155(7):1492-506. doi: 10.1016/j.cell.2013.11.040.
Genome analyses of single human oocytes.
Hou Y1Fan W2Yan L1Li R1Lian Y1Huang J1Li J1Xu L1Tang F3Xie XS4Qiao J5.

Science. 2012 Dec 21;338(6114):1622-6. doi: 10.1126/science.1229164.
Genome-wide detection of single-nucleotide and copy-number variations of a single human cell.
Zong C1Lu SChapman ARXie XS.

Science. 2012 Dec 21;338(6114):1627-30. doi: 10.1126/science.1229112.
Probing meiotic recombination and aneuploidy of single sperm cells by whole-genome sequencing.
Lu S1Zong CFan WYang MLi JChapman ARZhu PHu XXu LYan LBai FQiao JTang FLi RXie XS.

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